Seven Deadly SENS

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Seven Deadly SENS

Postby cactuspete » Mon Jun 19, 2017 7:42 am

Strategies for Engineered Negligible Senescence
This is a framework for undoing the effects of the aging process. By fighting elements in each category it is hoped that the effects of aging can be undone in the same way that cars are maintained through a combination of techniques which undo the effects of normal wear and tear on the fluids and parts, etc.
De Grey defines aging as "the set of accumulated side effects from metabolism that eventually kills us", and, more specifically, as follows: "a collection of cumulative changes to the molecular and cellular structure of an adult organism, which result in essential metabolic processes, but which also, once they progress far enough, increasingly disrupt metabolism, resulting in pathology and death." He adds: "geriatrics is the attempt to stop damage from causing pathology; traditional gerontology is the attempt to stop metabolism from causing damage; and the SENS (engineering) approach is to eliminate the damage periodically, so keeping its abundance below the level that causes any pathology."

LINK: https://en.wikipedia.org/wiki/Strategies_for_Engineered_Negligible_Senescence
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Re: Seven Deadly SENS

Postby cactuspete » Mon Jun 19, 2017 7:47 am

The Seven Deadly SENS
Here's the list:
1) RepleniSENS - Stem cells and tissue engineering. Cell loss, tissue atrophy
2) OncoSENS - Removal of telomere-lengthening machinery. Cancerous cells
3) MitoSENS - Allotopic expression of 13 proteins. Mitochondrial mutations
4) ApoptoSENS - Targeted ablation. Death-resistant cells
5) GlycoSENS - AGE-breaking molecules; tissue engineering. Extracellular matrix stiffening
6) AmyloSENS - Immunotherapeutic clearance. Extracellular aggregates
7) LysoSENS - Novel lysosomal hydrolases. Intracellular aggregates
READ ALL ABOUT IT:
http://www.sens.org/research/introduction-to-sens-research
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Re: Seven Deadly SENS

Postby cactuspete » Mon Jun 19, 2017 7:50 am

Aubrey de Grey donates $13 million of his own wealth to SENS life extension
It's the combination of all seven strategies which could lead to vastly extended lifespan. Each single strategy has only negligible impact. It's as if someone took really good care of the tires on their car, but never bothered changing the oil...
Q – Which of your SENS strategies would success achieve the most additional healthy years?

AdG: No one strategy would achieve very much on its own – certainly not as much as ten years, probably not even five.

LINK: https://www.nextbigfuture.com/2013/07/aubrey-de-grey-donates-13-million-of.html
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Re: Seven Deadly SENS

Postby sandman » Mon Jun 26, 2017 3:06 pm

Healing from Within: The Promise of Regenerative Medicine
Here they talk about developing a regenerative medicine toolkit which can be used to a wide variety of patients. The problem is the development of this toolkit seems to be taking a long time and some of us don't have all that long before we'll something from that toolkit.
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Re: Seven Deadly SENS

Postby sandman » Mon Jun 26, 2017 3:13 pm

How It's Made Regenerative Medicine
Just in case you need some spare parts in the future! :unsure:
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Re: Seven Deadly SENS

Postby sandman » Mon Jun 26, 2017 3:22 pm

Introducing Lipogems : regenerative medicine
This is also an interesting technology. During the video I thought they were saying parasites at first and only later found out they were saying pericytes. Also, MSC stands for Mesenchymal Stem Cell
LINK: https://en.wikipedia.org/wiki/Mesenchymal_stem_cell
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Re: Seven Deadly SENS

Postby cactuspete » Tue Jun 27, 2017 9:17 am

Aubrey de Grey: For a Long Life, Listen to Your Body
Interesting advice. It sounds like although he doesn't go to the doctor very often, he does have access to biometric tests which give him a lot of info that normal people would only be able to get through their doctor!
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Re: Seven Deadly SENS

Postby wildrose » Thu Jul 13, 2017 8:33 am

Aubrey de Grey - 7 Deadly Causes of Aging
A quick rundown on the seven SENS, but reworded a bit.
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Re: Seven Deadly SENS

Postby panamint_patty » Fri Jul 28, 2017 9:22 am

Seven Deadly SENS
It looks like blackturtle.us is a SENner just like the rest of us!
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Re: Seven Deadly SENS

Postby panamint_patty » Fri Jul 28, 2017 9:24 am

Is it Possible to Defeat Death? SENS Research Over 9000! | Ask an Expert | Singularity University
Fun interview with the head SENner himself! :thumb:
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