Seven Deadly SENS

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Seven Deadly SENS

Postby cactuspete » Mon Jun 19, 2017 7:42 am

Strategies for Engineered Negligible Senescence
This is a framework for undoing the effects of the aging process. By fighting elements in each category it is hoped that the effects of aging can be undone in the same way that cars are maintained through a combination of techniques which undo the effects of normal wear and tear on the fluids and parts, etc.
De Grey defines aging as "the set of accumulated side effects from metabolism that eventually kills us", and, more specifically, as follows: "a collection of cumulative changes to the molecular and cellular structure of an adult organism, which result in essential metabolic processes, but which also, once they progress far enough, increasingly disrupt metabolism, resulting in pathology and death." He adds: "geriatrics is the attempt to stop damage from causing pathology; traditional gerontology is the attempt to stop metabolism from causing damage; and the SENS (engineering) approach is to eliminate the damage periodically, so keeping its abundance below the level that causes any pathology."

LINK: https://en.wikipedia.org/wiki/Strategies_for_Engineered_Negligible_Senescence
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Re: Seven Deadly SENS

Postby cactuspete » Mon Jun 19, 2017 7:47 am

The Seven Deadly SENS
Here's the list:
1) RepleniSENS - Stem cells and tissue engineering. Cell loss, tissue atrophy
2) OncoSENS - Removal of telomere-lengthening machinery. Cancerous cells
3) MitoSENS - Allotopic expression of 13 proteins. Mitochondrial mutations
4) ApoptoSENS - Targeted ablation. Death-resistant cells
5) GlycoSENS - AGE-breaking molecules; tissue engineering. Extracellular matrix stiffening
6) AmyloSENS - Immunotherapeutic clearance. Extracellular aggregates
7) LysoSENS - Novel lysosomal hydrolases. Intracellular aggregates
READ ALL ABOUT IT:
http://www.sens.org/research/introduction-to-sens-research
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Re: Seven Deadly SENS

Postby cactuspete » Mon Jun 19, 2017 7:50 am

Aubrey de Grey donates $13 million of his own wealth to SENS life extension
It's the combination of all seven strategies which could lead to vastly extended lifespan. Each single strategy has only negligible impact. It's as if someone took really good care of the tires on their car, but never bothered changing the oil...
Q – Which of your SENS strategies would success achieve the most additional healthy years?

AdG: No one strategy would achieve very much on its own – certainly not as much as ten years, probably not even five.

LINK: https://www.nextbigfuture.com/2013/07/aubrey-de-grey-donates-13-million-of.html
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