Massive research studies on vitamin supplementation show that otherwise healthy people taking excessive doses of antioxidant vitamins do not reap the benefits of increased lifespan. In fact, as a recent report on deadly vitamins shows, excessive doses of vitamins can be hazardous to your health.
This anti-ageing phenomenon has been an unexpected twist in the study of senescent cells, a common, non-dividing cell type first described more than five decades ago. When a cell enters senescence — and almost all cells have the potential to do so — it stops producing copies of itself, begins to belch out hundreds of proteins, and cranks up anti-death pathways full blast. A senescent cell is in its twilight: not quite dead, but not dividing as it did at its peak. Now biotechnology and pharmaceutical companies are keen to test drugs — known as senolytics — that kill senescent cells in the hope of rolling back, or at least forestalling, the ravages of age.
1) Genomic Instability
2) Telomere Attrition
3) Epigentic Alterations
4) Loss of Proteostasis
5) Deregulated Nutrient Sensing
6) Mitochondrial Dysfunction
7) Cellular Senescence
8) Stem Cell Exhaustion
9) Altered Intercellular Communication
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